Protein name:
Protein Mdm4 ;
Alternative:
Mdm2-like p53-binding protein ;Double minute 4 protein ;p53-binding protein Mdm4 ;Protein Mdmx ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Found in a trimeric complex with UPB2, MDM2 and MDM4. Interacts with USP2 (By similarity). Interacts with MDM2, TP53 and TP73.
Function:
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. The short isoform is a more potent inhibitor of TP53 activity than the long isoform.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MTSHSTSAQC | SASDSACRIS | SEQISQVRPK | LQLLKILHAA | GAQGEVFTMK |
100:
EVMHYLGQYI | MVKQLYDQQE | QHMVYCGGDL | LGDLLGCQSF | SVKDPSPLYD |
150:
MLRKNLVTSA | SINTDAAQTL | ALAQDHTMDF | PSQDRLKHGA | TEYSNPRKRT |
200:
EEEDTHTLPT | SRHKCRDSRA | DEDLIEHLSQ | DETSRLDLDF | EEWDVAGLPW |
250:
WFLGNLRNNC | IPKSNGSTDL | QTNQDIGTAI | VSDTTDDLWF | LNETVSEQLG |
300:
VGIKVEAANS | EQTSEVGKTS | NKKTVEVGKD | DDLEDSRSLS | DDTDVELTSE |
350:
DEWQCTECKK | FNSPSKRYCF | RCWALRKDWY | SDCSKLTHSL | STSNITAIPE |
400:
KKDNEGIDVP | DCRRTISAPV | VRPKDGYLKE | EKPRFDPCNS | VGFLDLAHSS |
450:
ESQEIISSAR | EQTDIFSEQK | AETESMEDFQ | NVLKPCSLCE | KRPRDGNIIH |
489:
GKTSHLTTCF | HCARRLKKSG | ASCPACKKEI | QLVIKVFIA
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Bovine
ELISA Kit for Mouse Protein Mdm4
ELISA Kit for Mouse Protein Mdm4
ELISA Kit for Mouse Protein Mdm4
ELISA Kit for Mouse Protein Mdm4
CLIA Kit for Mouse Protein Mdm4
CLIA Kit for Mouse Protein Mdm4
CLIA Kit for Mouse Protein Mdm4
CLIA Kit for Mouse Protein Mdm4
Polyclonal Antibody for Mouse Protein Mdm4
Polyclonal Antibody for Mouse Protein Mdm4
Polyclonal Antibody for Mouse Protein Mdm4
Polyclonal Antibody for Mouse Protein Mdm4
Monoclonal Antibody for Mouse Protein Mdm4
Monoclonal Antibody for Mouse Protein Mdm4
Monoclonal Antibody for Mouse Protein Mdm4
Monoclonal Antibody for Mouse Protein Mdm4
Protein for Mouse Protein Mdm4
Protein for Mouse Protein Mdm4
Protein for Mouse Protein Mdm4
Protein for Mouse Protein Mdm4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
tissue :
Embryo .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
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Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
strain :
C57BL/6J .
tissue :
Thymus .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]